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While not recommended as a general screen, screening for iron overload disease is recommended based on known risk factors.

Hereditary haemochromatosis or iron overload disease, is the most common genetic disease in populations of North European origin, with a gene frequency as high as 1 in 8. Haemochromatosis causes the iron from a person's diet to accumulate in the body's organs. Over a lifetime and without treatment, serious and even fatal health effects can result.

General population screening is not recommended in Australia but screening of first-degree relatives of affected persons may be considered.