Multiple sclerosis



Last Review Date: December 26, 2016


What is it?

Multiple sclerosis (MS) is a disorder of the central nervous system characterised by inflammation of the fatty covering of the nerve fibres that join the nerve cells in the brain and spinal cord. The inflammation destroys this covering, the myelin sheath, leaving scar tissue. The affected nerve cells cannot transmit or receive impulses, so there are a variety of effects on muscle function and sensation.

The exact cause is unknown, but it seems likely that MS is an autoimmune condition in which white blood cells called T-cells attack the myelin sheath of the nerve fibres. It may be slightly more common in certain family groups suggesting an inherited predisposition, and it may be triggered by a viral infection.

MS occurs most often in young adults between the ages of 20 and 40 years, with a higher incidence among women. There are over 23,000 people diagnosed with MS in Australia.

The symptoms may come and go; relapses and remissions lasting from days to months. The signs of MS are many and varied. Some of the more common symptoms include pain, weakness, paralysis or tremor of any of the extremities; numbness or tingling in any area, facial pain, vision problems, difficulty walking and loss of balance.

Tests

In addition to a history of two or more relapses and remissions, and the presence of neurologic signs, tests that may indicate the presence of MS include:

  • Head and spine MRI scans showing scarring or a lesion. This is a non-invasive procedure that produces a picture of the area being filmed using magnets and radio waves but no radioactivity. Pictures or ‘slices’ are taken at specified intervals. These pictures are in colour and may be three-dimensional, showing details of the nerves.
  • Lumbar puncture showing two or more protein bands in the spinal fluid. A needle is inserted into an area of the spine, between vertebrae, and a small amount of fluid is withdrawn. A number of tests may be run on this fluid, including an immunoelectrophoresis to detect the presence of oligoclonal protein bands.
Treatment

Treatment options include injection of drugs as well as oral medication that can affect the immune system, altering inflammatory pathways, and steroids to lessen the severity of an attack. Physical, speech, and occupational therapy may be helpful as the condition progresses.


Related pages

On this site
Conditions: Autoimmune disorders

Elsewhere on the web
Better Health Channel: Multiple sclerosis - common problems
Healthdirect Australia: Multiple sclerosis
MS Australia