Samples that are easy to reach
Some samples are collected by simply running a swab over the affected area. Throat, nasal, vaginal, and wound cultures, for example, are obtained in this way. The procedures, while they may be uncomfortable, are generally quick and painless and have no after-effects. Procedures of this type can be performed at the point of care (in a clinic, in your doctor's surgery, or at the hospital bedside). The sample may then be sent to a laboratory for analysis (although a few tests provide bed-side results in just a few minutes).
Secretions and tissues from the female reproductive system—Samples of vaginal secretions are obtained by running a cotton swab over the walls of the vagina; cervical cells for a smear test are obtained using a cotton swab and spatula (called a speculum) or a tiny brush. Both procedures are painless.
Endometrial tissue samples are obtained by inserting a thin, flexible hollow tube into the uterus, during which you may feel a slight pinch or brief cramping. Patients may feel embarrassed or vulnerable because of how these samples are collected. Some patients find the position of the legs uncomfortable, some complain that the stirrups and speculum are cold, and some feel slight pressure as the speculum is inserted. A sensitive approach by the health care professional contributes greatly to the woman’s emotional comfort.
If you are physically uncomfortable, try asking for what you need (such as a smaller speculum). Also, if you would be more at ease if a woman performs these procedures, or if another female attendant is in the room when the procedure is performed, ask your practitioner to arrange for these.
Various cultures (nasal, throat, wound)—The specimen is collected by running a swab over the area of interest. People typically respond to swabbing of their throat with a momentary "gag" reflex. If the throat is sore, the sample collection, brief as it is, can be uncomfortable. Similarly, a nasal swab may be a bit uncomfortable as the swab is inserted and reaches areas inside the nose that are typically never touched.
Try to remember that the discomfort is temporary and ask your practitioner if there are ways to minimise any soreness that may result. You may also find it helpful to perform relaxation techniques before, during, or after the procedure.