Hodgkin's LymphomaIn 1832, Thomas Hodgkin described a malignant disease of the lymph nodes. In 1898 a characteristic abnormal cell - the Reed-Sternberg cell - was identified.
Hodgkin’s lymphoma (HL) is seen most often in adults between 15 and 40 years of age but can occur at any age and is slightly more common in males than in females.
There are many different theories concerning the cause of HL. Some think a
virus might be involved.
Similar to the classification of
non-Hodgkin's lymphoma, HL can be subdivided based on the structure of the abnormal lymph node and the types of cells that are present. Lymph nodes may have a predominance of small
lymphocytes, the presence of bands of fibrosis, a mixture of cell types, or lymphocyte depletion. "Nodular lymphocyte-predominant" HL behaves very differently from "classical" HL and should be considered in its own right.
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