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Viral hepatitis


Summary table: most common causes of viral hepatitis

Virus HepatitisĀ A Hepatitis B Hepatitis C
Transmission route Faecal-oral Infected needle or blood, sexual contact Infected needle or blood, sexual contact
Incubation time (acute infection) 15-50 days 45-160 days 14-180 days
Onset Sudden Either sudden or slow, unnoticed Usually slow, unnoticed
Severity Mild Occasionally severe Usually slow-developing and symptoms not specific or strong
Chronic form? No Yes Yes
Associated with other diseases? None Liver cancer, cirrhosis Liver cancer, cirrhosis
Testing to diagnose acute infection HAV-Ab, IgM HBsAg, Anti-HBc, IgM Anti-HCV, HCV RNA (note - may have same results as in chronic hepatitis)
Testing to diagnose chronic infection or to monitor treatment N/A HBsAg, HBV DNA, HBeAg, Anti-HBe Anti-HCV (once), HCV RNA or viral load, HCV genotype (once)
Tests that detect previous infection HAV-Ab, IgG Anti-HBs, Anti-HBc total Anti-HCV
Vaccine available? Yes Yes No
Common treatment None Chronic form - Interferon, entecavir, tenofovir, lamivudine, adefovir Chronic form - Interferon (usually with ribavirin)

Abbreviations defined

HAV-Ab = Hepatitis A Antibody
Anti-HBs = Hepatitis B surface antibody
HBsAg = Hepatitis B surface antigen
HBeAg = Hepatitis B e-antigen
Anti-HBe = Hepatitis B e-antibody
Anti-HBc = Anti-hepatitis B core antigen
HBV DNA = Hepatitis B Virus (test for virus genetic material)
Anti-HCV = Hepatitis C Antibody
HCV RNA = Hepatitis C Virus (test for virus genetic material)
HCV Viral Load = A detection and/or count of the amount of virus in the blood
HCV Genotype = Determines the type of Hepatitis C present (1 of 6 types)