Conn's syndrome

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Treatment

The goal with treatment of Conn’s syndrome is to lower blood pressure to normal or near normal levels, decrease blood aldosterone levels, and resolve any electrolyte imbalance. The type(s) of treatment depend on the cause of the excess aldosterone secretion. If it is due to a single benign adrenal tumour, then the affected gland may be surgically removed. In many cases, this will completely resolve the high blood pressure and other associated symptoms, but in others some treatment will still be necessary to control blood pressure. If the primary hyperaldosteronism is due to a cancerous tumour (rare), then organs located next to the affected adrenal gland will need to be evaluated during surgery and more than the adrenal gland may need to be removed.

If the cause of the primary hyperaldosteronism cannot be determined (idiopathic) or appears to be due to hyperplasia in both adrenals, then surgery is usually not recommended. The patient’s condition will be treated with spironolactone (which blocks the action of aldosterone) and one or more blood pressure drug therapies.

Patients should consult with their doctors and, when indicated, with an endocrinologist (a specialist in the endocrine system). Treatment for primary hyperaldosteronism must often be adjusted to accommodate underlying high blood pressure, kidney disease, congestive heart failure, and a variety of other disorders.

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