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Meningitis is an of the membranes that cover the brain and spinal cord (the ). Encephalitis is an inflammation of the brain itself. Meningoencephalitis is an inflammation of both the brain and the meninges. These conditions are caused by a , , , or infection, but may also be non-infectious in origin. Meningitis and encephalitis can be or , and their severity can range from mild and self-limited to fatal. Their associated inflammation and swelling increases pressure on the brain and nerve tissue. This can hinder, or permanently damage, the function of nerves and brain.
Meningitis and encephalitis can also damage the blood-brain barrier that separates the brain from circulating blood and regulates the distribution of substances between the blood and . The blood-brain barrier helps keep large molecules, toxins, and most blood cells away from the brain. With the disruption of this barrier, white and red blood cells, immune system chemicals, toxins, increased amounts of protein, and the germs that cause inflammation may be found in the cerebral spinal fluid (CSF). CSF is a clear watery liquid that normally flows freely around the brain and spinal cord. With meningitis and encephalitis, the flow of CSF may slow or become obstructed, which can increase CSF pressure, increase pressure on the brain and spinal cord, and decrease blood flow to the brain.
Last Review Date: June 2, 2013